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pentobarbital decreases levels of panobinostat by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Robust CYP3A4 inducers can reduce panobinostat concentrations by ~70% and result in remedy failure.pentobarbital will decrease the extent or influence of siponimod by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Steer